A number of tourists were also wounded in the crash, they said, without giving further details.
"We unfortunately have to convey that German citizens have been killed and... injured in an accident on the Egyptian coast of the Red Sea," a German foreign ministry spokesman said.
"Foreign Minister (Guido) Westerwelle has activated the foreign ministry's crisis management group. The German ambassador is on the way to the site of the accident," he added. Road accidents are common in Egypt, largely due to bad road conditions and lax enforcement of traffic laws. On Friday, two Russian tourists were killed when their bus overturned near the Sinai resort of Nuweiba, police said. And on November 17, 47 Egyptian school children were killed when a train smashed into their bus in central Egypt.